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Tuesday, 01. January 2013 /

New Model of Epilepsy Using Human Brain Slices

The project of Mark Cunningham at the University of Newcastle aimed to refine the existing human epileptic in vitro model so that it fully captured the profile of electrographic events of the epileptic human electroencephalography (EEG), using electrophysiological, neuroanatomical and in silico computational techniques.


Project title:

New Model of Epilepsy Using Human Brain Slices  

Project leader:

Mark Cunningham  

Financial support:    
Project background:

Epilepsy is a serious and common chronic neurological disorder characterized by recurrent seizures, which are caused by abnormal synchronized neuronal discharges. As many as 6 million people in Europe currently have active epilepsy. This has major implications not only for health, but also for independent living, education and employment, mobility, and personal relationships.  

In 2011 a total of 420’127 animals were used for research on the nervous body system in the UK alone.  

The project of Mark Cunningham at the University of Newcastle aimed to refine the existing human epileptic in vitro model so that it fully captured the profile of electrographic events of the epileptic human electroencephalography (EEG), using electrophysiological, neuroanatomical and in silico computational techniques. About 30% of patients suffering from temporal lobe epilepsy have seizures that are resistant to drug therapy, and many of these are offered surgery to remove the part of the brain where the seizures initiate. Human brain tissue from such surgeries was collected and used for this project. The ability to conduct detailed scientific studies on human brain tissues from patients actually suffering from epilepsy allowed a unique insight into the disease.      

Milestones/Timeline:

2013-2014  

Publications:      
Updates:    
Keywords: