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Academic studies


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Academic studies  

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Animalfree Research supported a variety of graduate theses over the years of its existence. Assistance was given by partially financing the scientific work but also by offering expertise and knowledge. Here we list some examples:   PhD thesis of Hildegard Kohlhauf Albertin at the Swiss Federal Institute of Technology in Zurich (1988) This work assessed the use of uterus tissue of female sheep, collected from slaughterhouse waste, for testing hormone supplements. Commonly, these compounds are tested on rat tissue and typically the rats are specifically sacrificed for this purpose. The new method, using sheep tissue, could be used as an initial screening test for uterotonic substances.   

PhD thesis of Kristina Peters, Faculty for Veterinary Medicine, Ludwig-Maximilians University, Munich (2007): The author aimed to use the isolated perfused porcine kidney model to elicit answers to fundamental questions about high-intensity focused ultrasound (HIFU). In oncology, the use of HIFU was becoming increasingly appreciated as a completely non-invasive therapy and a valid alternative to conventional surgery. Peters’ findings showed that using HIFU in kidney tissue can induce precisely circumscribed homogeneous lesions with irreversible cell devitalisation. It proved possible to control lesion size and also ablate clinically relevant tissue volumes.  

Dissertation of Suzan Commandeur, Department of Dermatology of the Leiden University Medical Centre, Netherlands (2013): The aim of this research was to develop a representative in vitro model of human squamous cell carcinoma (SCC) for screening potential therapeutic compounds. SCC comprises about 15% of all skin cancer diagnoses. The author generated several three-dimensional in vitro SCC models in which the malignant epidermal cancer cells were either represented by intact primary human cutaneous or by established, spontaneously immortalized human cutaneous SCC cell lines. In order to test the applicability of this new in vitro SCC model as a drug screening tool, it was validated with active compounds, with promising results, indicating that this skin cancer model adds to the spectrum of available in vitro models for therapeutic screening.    

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Kohlhauf Albertin H. (1988): Die Interaktion des Neurohypophysenhormons Oxytocin mit myometrialen Zellen des Schafs. ETH Zurich.  

Peters K. (2007): Experimentelle Untersuchungen zur nichtinvasiven Gewebeablation durch hochenergetischen fokussierten Ultraschall (HIFU). Tierärztlichen Fakultät der Ludwig-Maximilians-Universität, Munich.   Commandeur S. (2013): Organotypic in vitro models of human cutaneous squamous cell carcinoma. Leiden University.    

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